Closing Date Tuesday, 30th November 2021
Job Type Research
Department Biosciences, Animal Sciences
Salary £27924 to £40927 per annum, (pro rata if applicable) depending on skills and experience (minimum £31406 with relevant PhD). Salary progression beyond this scale is subject to performance
Applications are invited for a Research Associate/Fellow to work on a BBSRC funded project investigating cell fate regulation during gastrulation in the laboratory of Prof Ramiro Alberio (University of Nottingham), in collaboration with Prof Jennifer Nichols (University of Cambridge) and Prof Matt Loose (University of Nottingham).
The project investigates the molecular mechanisms of gastrulation in mammals. The investigations will include working with embryos and in vitro models, such as gastruloids, and using single cell genomics as a mean to understand cellular trajectories during differentiation. This position will especially suit candidates with interest in single cell RNA seq., embryology and micromanipulation. The successful candidate will use in vitro functional assays to model developmental trajectories using embryonic stem cells, as well as gene editing of pig zygotes to create embryonic mutants. All the technologies required for the project are currently performed in our laboratory. This post offers a unique opportunity to work in fast developing fields (synthetic embryology, single cell genomics and gene editing) and to develop skills in state-of-the-art technologies.
Applicants must be highly motivated and self-driven, with a PhD (or close to completion) or equivalent in biology or related biological science. The successful candidate will have excellent laboratory skills including cell culture (e.g., 3D culture) and molecular biology; evidence of research methodologies and techniques including such as hybridization chain reaction; and experience using R/Ilastik/Fiji for image analysis (often based on machine-learning algorithms).
An ability to analyse and interpret data, evaluate and criticise texts and bring new insights; data handling skills (RNA seq. data, quantitative image analysis); and experience in growing embryonic stem cells (or organoids/gastruloids), and quantitative imaging techniques would be an advantage.
This is a full-time (36.25 hours), fixed term post for post to 31st December 2022. Arrangements for job share would be considered.
For more information on our lab activities please visit: http://www.nottingham.ac.uk/Biosciences/People/ramiro.alberio
Informal enquiries may be addressed to Ramiro Alberio, email RAMIRO.ALBERIO@NOTTINGHAM.AC.UK. Please note that applications sent directly to this email address will not be accepted.
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