A position is available for a strongly motivated postdoc in the Centre for Molecular and Vascular Biology in the Cardiovascular Sciences department at KU Leuven, Belgium. The main focus of the lab is on vascular biology, with a focus on vascular remodelling physiologic and pathological adaptation of the blood vascular network. Project Heart Failure with preserved Ejection Fraction (HFpEF) occurs when the heart becomes stiffer and cannot fill with blood properly. It is also called diastolic heart failure. People who develop HFpEF often suffer from metabolic comorbidities such as hypertension, hyperlipidaemia, diabetes, obesity, as well as generally being older. HFpEF is associated with microvascular dysfunction and there is increasing evidence that microvascular dysfunction may drive disease progression. Most of the current research focuses on the role of endothelial cells, however endothelial cell physiology is strongly related to pericyte function. We have preliminary results showing that these cells are more sensitive to the metabolic comorbidities than the endothelial cells. The project would therefore be a combination of in vitro and in vivo work to study the effect of comorbidities on pericyte function.
• You will have your own dedicated research project studying pericyte physiology in the presence of comorbidities. You will work within a large an vibrant team that is specialized in HFpEF, in vascular biology, in mechanotransduction and in vascular development. You will therefore be exposed to a lot of different projects, research areas in vascular biology, and technologies.
• You will be responsible for administration and execution of the project. You are expected to have molecular biology skills (qPCR, Western blots, immunostaining), imaging skills (fluorescence and confocal imaging), cell culture and animal handling skills.
• The project will involve single cell RNA-Seq and therefore an interest or previous experience in genomics and bioinformatics is essential.
• The project will cardiac phenotyping in a mouse model. You will learn echocardiography, tail cuff measurements and other such techniques.
• You will be expected to present the work at conferences, lab meeting, and departmental meetings.
• The candidate must have a PhD in a relevant discipline (Molecular Biology, Genetics, Bioinformatics).
• Candidates must have experience in gene expression analysis on sequencing data sets. Experience in vascular biology and/or cardiac physiology is a benefit.
• Strong interest in pursuing a career in research.
• A good publication record, with at least one paper in a higher-impact journal.
• The candidate must be a highly motivated, enthusiastic and efficient researcher.
The current position is for 2 year, and you will be expected to apply for fellowships during the first year. The position can be extended, based on satisfactory progress.
For more information please contact Prof. dr. Elizabeth Jones, tel.: +32 16 32 24 44, mail: firstname.lastname@example.org.
You can apply for this job no later than April 15, 2021 via the online application tool
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|Title||Postdoctoral Position in Cardiac Microvascular Dysfunction in HFpEF|
|Job location||Oude Markt 13, 3000 Leuven|
|Published||March 1, 2021|
|Application deadline||April 15, 2021|
|Job types||Postdoc  |
|Fields||Physiology,   Biomedicine,   Bioinformatics,   Molecular Biology,   Medical Imaging,   Cardiology,   Genetics,   Cell Biology,   Vascular Medicine,    and 1 more. Computational Biology  |