Postdoctoral fellowship in bioinformatic analyses of genome wide patterns of gene trafficking (scholarship)

Do you want to contribute to top quality medical research?

Karolinska Institutet is one of the world´s leading medical universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.

Division

We are seeking a highly motivated postdoctoral researcher in bioinformatics to join a a research team dedicated to understand the function of 3D epigenome folding in relation to the nuclear architecture and its deregulation in human diseases. The candidate is expected to drive a postdoctoral project and participate in collaborative efforts to uncover hitherto unknown therapeutic targets in complex diseases, such as cancer. The work will be carried out at the department of Oncology and Pathology in the lab of Anita Göndör. We have innovated state-of-the-art techniques enabling the analysis of 3D chromatin structures and chromatin fibre networks in single cells and small cell populations to provide unique opportunities for novel discoveries. In addition, we have developed assay systems to score for genome wide analyses of gene trafficking and the involved regulators using siRNA libraries.

For further information about our work, please consult a selection of reports from our labs:

Nature. 2009 461, 212-7(2009); Mol Cell. 59:984-97 (2015); Nat Rev Genet. 17:284-99 (2016); Nature genetics. 51, 1723-1731 (2019); Science 359, 1212-1213 (2018); Mol Cell 59, 984-97 (2015); Nature genetics. 51, 1723–1731 (2019), Nucleic Acids Research, 48, 10867–10876 (2020); Nat Commun Jan 11;13:204 (2022); Nature protocol, 18:755-782 (2023)

Anita Göndörs group

Duties

The successful applicant will employ state-of-the-art bioinformatic techniques adapted to the analyses of single cells alongside more conventional ChIP-seq/cut&run-seq, RNA-seq and chromatin network analyses.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.
A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.
To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Other requirements

In addition, it is advantageous if the successful candidate has:

• Experience in the analysis of NGS data, in particular: RNA-seq, single cell RNA-seq, ChIP-seq, 3C-based chromatin interactome datasets
• Experience in network analysis
• Excellent knowledge in biostatistics
• Extensive experience in using R/BioConductor, Unix/Linux environment (prior scripting language experience e.g. Python/Perl is a plus)
• Experience in data visualization
• Experience in meta-analysis
• Experience in SNP calling from NGS data is a plus
• Proficiency in written and spoken English
• Good understanding of biological concepts and/or willingness to learn
• Experience in working with wet lab scientists

A high level of organizational and communication skills, as well as an ability to independently perform experiments and implement interpretation of data is mandatory.

Location: BioClinicum, Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

• A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
• A complete list of publications
• A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system. Apply at the latest 30^th June.

Want to make a difference? Join us and contribute to better health for all

1. Anita Göndör , anita.gondor@ki.se

1. Helen Eriksson, OFR, helen.eriksson@ki.se
2. Henry Wölling, Seko, henry.wolling@ki.se
3. Per Hydbring/Nick Tobin, SACO, per.hydbring@ki.se/nick.tobin@ki.se