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Gyroscope Therapeutics
Research Scientist / Senior Scientist, AAV Vectorology, Immunology & Ophthalmology
Gyroscope Therapeutics
The Company’s mission is to develop therapeutics against a set of diseases where no meaningful treatment options exist today. Syncona has co-ordinated a diverse set of domains from a number of different UK Universities to found the Company.
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JOB DETAILS
Published: 11 months ago
Application deadline: Unspecified
Location: United Kingdom
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Research Scientist / Senior Scientist, AAV Vectorology, Immunology & Ophthalmology

Location: Stevenage, SBC

Details:

Gyroscope’s research team is being expanded to develop and support an increasing portfolio of gene therapy medicines. The team is responsible for delivering the novel adeno associated virus (AAV) construct designs and early in vitro and in vivo proof of concept studies (PoC) for molecules in pre-clinical development. As a result Gyroscope is seeking 2-3 talented scientists spanning from AAV vector design and production, immunology and ophthalmology. The chosen candidates will help to support aspects of the projects from early phases and the subsequent transition to clinical development, to underpin and support subsequent manufacture and non clinical and clinical testing. The role will help to initiate and support the development of innovative improvements in the design, characterisation and manufacture of cell and gene therapy medicines.

Gyroscope is seeking  highly motivated and creative individuals to work within the research team. The successful candidates will use their understanding of molecular virology, immunology / virus-host cell interactions and ophthalmic techniques to develop improved candidates and constructs for use in the manufacture of vectors for clinical gene therapy.
 

These roles will give the chosen candidates an exciting opportunity to take novel and creative approaches to improving upon current state-of-the-art AAV production technology and subsequent application within a team that is applying AAV vectors to the transformational treatment of human disease. Experience in some or all of the following techniques: plasmid subcloning, vector production,  immunology and or ophthalmology is essential.

The successful candidates will join a rapidly growing world-class team and will have the opportunity to play a part in shaping the growth of this exciting new biotechnology start-up

Activities:

  • In-silico design, development and in vitro testing of novel plasmid constructs designs to enhance AAV production

  • Define, develop (as required) and employ innovative analytical techniques to characterise AAV vectors in vitro and in vivo

  • Conducting research experiments to support early candidate evaluation and subsequent selection

  • Ensuring all required documentation and experimental write-ups are completed and approved in a timely manner

  • To ensure validity and reliability of data at all times

  • To prepare material for presentation, patent filings and manuscripts for publication

  • To present findings to colleagues in weekly lab meetings

  • To assist in the supervision of technicians and junior researchers

  • Writing research operating procedures and reports as required

  • Provide support for meeting management, action follow-up to ensure adherence to agreed milestones

  • Cross-functional working with other departments in Gyroscope

  • Management and scientific oversight of external programmes

Basic Qualifications (some or all competencies below need to be met)

  • PhD or equivalent number of years of experience in Molecular Virology, Immunology, Ophthalmology or related discipline

  • Experience of methods for the design and generation of biopharmaceutical viral vectors

  • Advanced molecular and cell biology techniques, including gene cloning, protein expression, antibody production, western blot analysis and protein immune-localization, fluorescence and confocal microscopy.

  • Ability to apply scientific and technical expertise in molecular biology and tissue engineering to impact the future of new drug candidate development for clinical use

  • Ability to generate the necessary preclinical data with lead candidate to support proof-of-concept clinical trial

  • Ability to work to priorities and deliver projects on time

  • High level analytical capability

  • Ability to communicate complex information clearly

  • Ability to apply relevant models, techniques and methods and develop new ones

  • Ability to assess resource requirements and deploy them effectively

  • Ability to encourage research culture in others

Preferred qualifications:

  • Knowledge and experience of the molecular biology of adeno-associated viruses (AAV)

  • Knowledge of interactions between viruses and host cell biology

  • Understanding of the early stage drug development process ideally for biopharmaceutical or cell/gene therapy products

The application should include a one page letter outlining how you meet the required competencies for this role at Gyroscope Therapeutics as outlined in the job requirements above. This letter should be accompanied by a two page C.V.  Interested applicants should submit their applications to i.pitfield@gyroscopetx.com.   

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