European Synchrotron Radiation Facility (ESRF)

PhD Thesis Student (f/m) on ID30B in the Structural Biology group

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The European Synchrotron, the ESRF, is an international research centre based in Grenoble, France.

Through its innovative engineering, pioneering scientific vision and a strong commitment from its 700 staff members, the ESRF is recognised as one of the top research facilities worldwide. Its particle accelerator produces intense X-ray beams that are used by thousands of scientists each year for experiments in diverse fields such as biology, medicine, environmental sciences, cultural heritage, materials science, and physics.

Supported by 21 countries, the ESRF is an equal opportunity employer and encourages diversity.

Subject: Probing protein dynamics by single-crystal room temperature, or high-pressure cryogenic, crystallography and in crystallo optical spectroscopy You will join the Structural Biology Group to pursue a project aimed to propose a new paradigm in macromolecular crystallography (MX) by focusing on room temperature data collection and embracing complementary biophysical approaches. Single-crystal room temperature MX has the potential to probe proteins dynamics, benefitting from the use of complementary techniques (e.g., optical spectroscopy, high-pressure) directly used on crystalline samples. This integrated project, combining MX, in crystallo optical spectroscopy (icOS) and high-pressure MX (HPMX), will study several fluorescent proteins in order to provide a comprehensive picture of their dynamics to help tune their properties.

Further information may be obtained from Christoph Mueller-Dieckmann (tel.: +33 (0)4 76 88 28 70, email: or Antoine Royant (tel.: +33 (0)4 76 88 28 70, email:

- Degree allowing enrolment for a PhD (such as MSc, Master 2 de Recherche, Laurea or equivalent) in biology, biophysics or a closely related science

- A background in structural biology or biophysical methods is desirable

- Ability to interact within a multi-disciplinary team

- Wide interest between instrumentation, methodology and applied biological research

- Proficiency in English (working language at the ESRF)

Your shall be enrolled in Université Grenoble Alpes / Chemistry & Life Doctoral School as a condition of your recruitement.

Contract of two years renewable for one year.

Do you recognize yourself in this description? Apply now for your next professional adventure!What we offer:

- Join an innovative international research institute, with a workforce from 38 different countries

- Collaborate with global experts to advance science and address societal challenges

- Come and live in a vibrant city, in the heart of the Alps, and Europe's Green Capital 2022

- Enjoy a workplace designed to support your quality of life

- Benefit from our competitive compensation and allowances package, including financial support for your relocation to Grenoble For further information on employment terms and conditions, please refer to

The ESRF is an equal opportunity employer and encourages applications from disabled persons.

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PhD Thesis Student (f/m) on ID30B in the Structural Biology group
71 avenue des Martyrs Grenoble, France
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The ESRF is an X-ray light source for Europe. It is located in Grenoble, France, and supported and shared by 20 countries.

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