The Institute for Food, Nutrition and Health, belongs to the Department for Health Sciences and Technology. Here, engineers, materials scientists, biochemists and biologists work together to solve some of the most pressing societal issues, such as microbiota-associated and metabolic diseases.
Microbiota composition during early childhood is increasingly recognised as a major impact on health and development. In most cases, the molecular nature of this relationship remains a mystery. However, in intoxication-type inborn errors of metabolism, as well as in neonatal sepsis and necrotizing enterocolitis, we have a strong hypothesis for the function of the microbiota in disease. Moreover, these diseases have a pressing need for improved therapies and/or prophylaxis. This generates an ideal opportunity to develop and test microbiota engineering therapeutics, with a view to rapid clinical translation.
Our previous work has demonstrated the ability of intestinal antibodies to generate highly specific selective pressure in the intestine. Your project will develop gnotobiotic and humanized microbiota models of these diseases. These will then be used to test antibody- and CRISPR-based techniques to manipulate microbiota composition in situ. In collaboration with a team of molecular biologists, clinicians, metabolism experts and neuroscientists, it will then map the molecular details of microbiota-disease interactions and the extent of amelioration achievable by microbiota engineering.
Via linked NCCR and ERC funded projects, this position is expected to take fundamental progress in vaccine development and microbiota network function and to translate this into clinically highly relevant disease models, with an aim to rapidly develop human therapies. There is considerable potential to develop the project independently and/or to link with ETH spin-outs for knowledge transfer.
This position will be co-supervised by Prof. Emma Slack (Food Immunology, ETH Zurich) and Johannes Häberle (Kinderspital, University of Zurich).
Starting date: Open
We are looking for an outstanding postdoctoral researcher interested in working within an interdisciplinary team and in translating fundamental research to clinical practice. A strong background in gnotobiotic mouse models, microbial consortium assembly, microbiology, metabolism and/or mucosal immunology will be highly beneficial. Exceptional individuals interested in moving into this field from other biological disciplines will also be considered.
We look forward to receiving your online application including the following documents: Curriculum vitae, Statement of interests, contact details (email address and telephone number) of two people willing to give references. Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered.
For further information about the Food Immunology group please visit our website: www.foodimmunology.ethz.ch. Questions regarding the position should be directed to Prof. Emma Slack and Prof. Johannes Häberle by email: email@example.com and firstname.lastname@example.org (no applications).
|Title||Postdoctoral Reseacher: Precision microbiota engineering for child health|
|Job location||Rämistrasse 101, 8006 Zurich|
|Published||January 23, 2020|
|Job types||Postdoc  |
|Fields||Clinical Sciences,   Molecular Biology,   Microbiology,   Immunology,   Bioengineering  |