Eligibility: UK/EU graduates with the required entry requirements
Funding details: Bursary, tuition fees and generous consumables allowance
Duration: Full-Time (42 months)
Application deadline: 30th October 2020
Interview dates: Interview date in early August will be confirmed to shortlisted candidates
Start date: January 2021
To find out more about the project, please contact Professor Derek Renshaw
There is an emerging pattern of high COVID-19 disease severity and mortality in patients who are male gender, are obese, have type II diabetes mellitus, BAME and increasing age. This application will endeavor to elucidate the underlying mechanisms, which increase disease severity in these at risk groups.
A common feature of increased mortality in COVID-19 patients is an over-reaction of the patients innate immune system, the so called ‘cytokine storm’ part of the acute phase response to this viral infection. This feature is the body’s response to an infectious agent and leads to systemic blood clotting, organ failure and increased mortality risk.
The body’s defense against this is led by the counter regulatory immune system comprising of glucocorticoids and anti-inflammatory cytokines. This system represents our natural protection against over reaction of the innate immune system and is attenuated in obesity.
This project will develop a biological activity test to measure immune system activity in response to a safe, model coronavirus using white blood cells taken from participants in these high risk groups.
The results of this project will allow us to develop a simple blood test that will predict an individuals risk of innate immune system over reaction to a future Coronavirus infection.
This is a fully-funded PhD studentship, including:
The successful candidate will receive comprehensive research training including technical, personal and professional skills. All researchers at Coventry University (from PhD to Professor) are part of the Doctoral College and Centre for Research Capability and Development, which provides support with high-quality training and career development activities.
For further details see: https://www.coventry.ac.uk/research/research-students/making-an-application/
All applications require full supporting documentation, a covering letter, plus a 2000-word supporting statement showing how the applicant’s expertise and interests are relevant to the project.
To find out more about the project please contact Professor Derek Renshaw.Continue reading
|Title||Development of a leukocyte activity assay to predict COVID-19 disease severity|
|Job location||Priory Street Coventry, CV15FB|
|Published||July 20, 2020|
|Application deadline||October 30, 2020|
|Job types||PhD  |
|Fields||Biomedicine,   Immunology,   Epidemiology,   Infectious Diseases,   Health Science  |