Yeasts are valuable hosts for production of heterologous proteins. The aim of this project is to identify and engineer promoters of the methylotrophic yeast Pichia pastoris that are specific growth conditions in bioreactor cultures, and to validate their performance.
Within this project we aim to develop a P. pastoris expression platform that is specifically designed for its performance in non-standard bioreactor setups and cultivation conditions. Gene expression data will be used to identify suitable promoters, which will be further engineered based on computational analysis of their structure. Performance of the newly designed promoters will be evaluated in bioreactors and the best performing will be implemented in the expression platform.
Research will take place in the group “Metabolic and Cell Engineering” at the Institute of Microbiology and Microbial Biotechnology at the University of Natural Resources and Life Sciences Vienna (BOKU) https://boku.ac.at/dbt/immb/research-groups/mattanovich-lab-metabolic-and-cell-engineering
Application deadline: 20.4.2021
Start: May-June 2021
Please apply by email to firstname.lastname@example.org with a single PDF file containing: Ref. No. #01_2021 a detailed CV and publication list, a motivation letter, copies of university degree documents, contact information (phone number and email) and contact details of up to 3 academic referees
Contact: Prof. Dr. Diethard MATTANOVICH
We are dedicated to a well-balanced gender ratio, therefore this job advertisement addresses qualified male and female persons equally. The employment contract is classified as group B1 of the Austrian collective agreement for university employees. Min. gross salary: € 3945 per month (14x per year).Continue reading
|Title||Post Doc Position on Promoter Engineering of Pichia pastoris for Customised Protein Production|
|Employer||BOKU University of Natural Resources and Life Sciences|
|Job location||Gregor-Mendel-Straße 33, 1180 Vienna|
|Published||April 8, 2021|
|Application deadline||April 20, 2021|
|Job types||Postdoc  |
|Fields||Biotechnology,   Chemical Engineering,   Biochemistry,   Molecular Biology,   Microbiology,   Genetics,   Bioengineering,   Computational Biology  |