The Research Training Group 2202 „Transport across and into membranes“
at the University of Freiburg (Germany) welcomes applications for
1 PhD position “Integrative Membrane Structural Biology”
Part-time position (65%), next possible date
The Research Training Group is funded by the DFG and focuses on the characterization of transport processes at a molecular level. The doctoral researchers examine the transport of ions, metabolites and proteins across and in the cell membrane using a huge variety of biochemical and biophysical techniques.
The three‐year structured program consists of lecture series, seminars, method courses, a summer school, and symposia. In addition, participants will be offered the possibility to attend courses for individual needs. Successful candidates will be awarded the PhD degree (Dr. rer. nat.). The program is taught in English.
The PhD position is open in the Institute for Biochemistry and Molecular Biology, in the Hunte laboratory (http://www.biochemie.uni-freiburg.de/ag/hunte/).
Sodium/proton exchangers (NHEs) are integral membrane proteins with crucial roles in control of cell and tissue pH. NHEs exchange sodium ions against protons across cellular membranes in a highly regulated manner and are key players in essential physiological processes such as growth, proliferation and differentiation of cells. Their dysfunction is linked to a broad range of pathophysiological conditions including cardiac and neurological diseases as well as cancer, and they serve as drug targets. Yet, the molecular mechanisms and underlying structure-function relationships are rarely understood. The project aims to elucidate structural and functional determinants of regulated ion translocation by NHEs. We will address fundamental open questions with a broad spectrum of genetic, biochemical and biophysical methods including X‐ray crystallography and cryo electron microscopy. Focus will be on mammalian NHE1 and its regulation by calcineurin B homologous proteins (CHPs). Previous work of the group includes structure determination of NhaA (Hunte et al. Nature 2005), a bacterial homolog, and characterization of the interaction between CHPs and NHE1 (Fuchs et al. Sci. Rep. 2018, Liang et al. FASEB J. 2020).
We are offering a dedicated research environment with state of the art equipment for membrane protein research. The group is member of the excellence cluster CIBSS – Centre for Integrative Biological Signalling studies (https://www.cibss.uni-freiburg.de). We are seeking highly motivated and qualified individuals with a keen interest in molecular biomedical research. Candidates should hold a university degree (Master or equivalent) in biochemistry, chemistry, biology or a related topic. The position is available from September 2020 until filled.
For further information, please contact Carola Hunte (Email: firstname.lastname@example.org). The PhD position will be associated to the Research Training Group 2202 "Transport across and into membranes" (www.taim-uni-freiburg.de).
The maximum duration of the PhD position will be three years. The salary is in accordance with the German public service salary scale (TV‐L E 13, 65%).
Further information: www.taim.uni-freiburg.de
Applications should be sent as one pdf file to email@example.com
Please refer to „Application RTG 2202“ in the subject line.Continue reading
|Title||1 PhD position “Integrative Membrane Structural Biology”|
|Employer||Albert-Ludwigs-University of Freiburg|
|Job location||Friedrichstr. 39, 79098 Freiburg|
|Published||July 31, 2020|
|Job types||PhD  |
|Fields||Physiology,   Biochemistry,   Structural Biology,   Molecular Biology,   Cell Biology,   Chemical Biology,   Pharmacy & Pharmacology,   Molecular Medicine  |